Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 10/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.47 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13320317 | 0.91 | KCNH2 (0.49) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL483828 | 0.90 | KCNH2 (0.53) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2833097 | 0.90 | KCNH2 (0.59) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| Hydrochloric Acid SCHEMBL2836765 | 0.89 | KCNH2 (0.58) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2830545 | 0.88 | KCNH2 (0.47) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2832206 | 0.86 | KCNH2 (0.61) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL10167542 | 0.86 | KCNH2 (0.61) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| Hydrochloric Acid SCHEMBL2831125 | 0.85 | KCNH2 (0.60) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL2839844 | 0.81 | KCNH2 (0.47) | KCNH2SCN3ASCN9ASCN1ASCN4A | |
| SCHEMBL14041366 | 0.81 | KCNH2 (0.56) | KCNH2SCN3ASCN9ASCN1ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100130583-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | US | disclosed |
| US-20100130583-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | US | disclosed |
| EP-2129655-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | Glaxo Group Limited (GB) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008122546-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130583-A1 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | SCN1A, SCN3A, SCN2A | KCNH2 22/4885SCN3A 2/4885SCN9A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.