Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.45 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.45 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377742 | 0.92 | HRH3 (0.66) | HRH3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4377220 | 0.91 | HRH3 (0.65) | HRH3KMT2AMEN1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL4378100 | 0.90 | HRH3 (0.66) | HRH3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL5233881 | 0.88 | HRH3 (0.59) | HRH3KMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL5235270 | 0.88 | HRH3 (0.59) | HRH3KMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL5233892 | 0.88 | HRH3 (0.59) | HRH3KMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL4375706 | 0.82 | HRH3 (0.62) | HRH3ALDH1A1KDM4EL3MBTL1POLB | |
| SCHEMBL4379469 | 0.81 | HRH3 (0.64) | HRH3KMT2AALDH1A1KDM4E | |
| SCHEMBL4388156 | 0.81 | HRH3 (0.64) | HRH3KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL14190992 | 0.81 | HRH3 (0.61) | HRH3KMT2AALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |