Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381778 | 0.89 | PLK1 (0.67) | PLK1GFERDEGS1MTNR1AGAA | |
| SCHEMBL26885152 | 0.79 | AURKA (0.50) | PLK1GFERDEGS1GAAMMP3 | |
| SCHEMBL23581544 | 0.77 | TLR8 (0.47) | GFERDEGS1GAATLR8PTPN1 | |
| SCHEMBL273978 | 0.76 | CA12 (0.54) | GFERGAATLR8PTPN1ALDH1A1 | |
| SCHEMBL30571222 | 0.76 | CA12 (0.54) | GFERGAATLR8PTPN1ALDH1A1 | |
| SCHEMBL29406872 | 0.75 | PTPN1 (0.68) | GFERPTPN1CDC25BALDH1A1 | |
| SCHEMBL29535167 | 0.75 | PTPN1 (0.68) | GFERPTPN1CDC25BALDH1A1 | |
| SCHEMBL273841 | 0.75 | PTPN1 (0.68) | GFERPTPN1CDC25BALDH1A1 | |
| SCHEMBL5773533 | 0.75 | SMYD3 (0.55) | NPC1RAB9AAURKALCKMET | |
| Hydrochloric Acid SCHEMBL3917199 | 0.74 | PTPN1 (0.66) | GFERPTPN1CDC25BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110551065-A | Deuterated Lucistanib compound and application thereof | HINOVA PHARMACEUTICALS INC | 2019-12-10 | — | — | CN | disclosed |