Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 18/20 | 0.75 |
| ▸ | CCNH | P51946 | 16/20 | 0.75 |
| ▸ | CDK9 | P50750 | 15/20 | 0.75 |
| ▸ | CCNK | O75909 | 14/20 | 0.75 |
| ▸ | CDK12 | Q9NYV4 | 14/20 | 0.75 |
| ▸ | CCNT1 | O60563 | 13/20 | 0.75 |
| ▸ | CDK2 | P24941 | 13/20 | 0.75 |
| ▸ | MNAT1 | P51948 | 11/20 | 0.75 |
| ▸ | CDK13 | Q14004 | 11/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.57 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.57 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.57 |
| ▸ | JUN | P05412 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18072745 | 0.90 | CDK7 (0.88) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL16665178 | 0.90 | CDK7 (0.88) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL18047265 | 0.90 | CDK7 (0.88) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL16665179 | 0.90 | CDK7 (0.88) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL16654786 | 0.88 | CDK7 (0.74) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL28345975 | 0.86 | CDK7 (0.81) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL29366824 | 0.86 | CDK7 (1.00) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL17150697 | 0.86 | CDK7 (1.00) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL18072813 | 0.86 | CDK7 (0.76) | CDK7CCNHCDK9CCNKCDK12 | |
| SCHEMBL16654788 | 0.85 | CDK7 (0.71) | CDK7CCNHCDK9CCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105849099-B | Polycyclic inhibitors of cyclin dependent kinase 7(CDK7) | 达纳-法伯癌症研究所股份有限公司 | 2020-01-17 | — | — | CN | disclosed |