Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 18/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | MAT2A | P31153 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003408 | 0.87 | APP (0.77) | APPKCNH2MAT2A | |
| SCHEMBL9680312 | 0.87 | APP (0.77) | APPKCNH2MAT2A | |
| SCHEMBL9678907 | 0.87 | APP (0.77) | APPKCNH2MAT2A | |
| SCHEMBL900823 | 0.87 | APP (0.77) | APPKCNH2MAT2A | |
| SCHEMBL13892897 | 0.86 | APP (0.74) | APPKCNH2MAT2A | |
| SCHEMBL2289242 | 0.84 | APP (0.72) | APPKCNH2MAT2A | |
| SCHEMBL16614459 | 0.84 | APP (0.72) | APPKCNH2MAT2A | |
| SCHEMBL6880493 | 0.84 | APP (0.72) | APPKCNH2MAT2A | |
| SCHEMBL9999669 | 0.80 | APP (0.67) | APPKCNH2MAT2A | |
| SCHEMBL22880747 | 0.80 | APP (0.67) | APPKCNH2MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858072-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-12-28 | — | — | US | disclosed |
| EP-1838298-A4 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1838298-A2 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | The Trustees of The University of Pennsylvania (US) | 2007-10-03 | — | — | EP | disclosed |
| US-20060269474-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-11-30 | — | — | US | disclosed |
| WO-2006078384-A2 | STILBENE DERIVATIVES AND THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060269474-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | APP, APBA1, PSEN1 | APP 1/4885KCNH2 4102/4885MAT2A 3029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.