Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29555021 | 1.00 | EPHX2 (0.39) | EPHX2MDM4TP53DCUN1D1CASP3 | |
| SCHEMBL30714788 | 0.90 | MDM4 (0.43) | EPHX2MDM4TP53CASP3MDM2 | |
| SCHEMBL29555034 | 0.89 | EPHX2 (0.38) | EPHX2MDM4TP53DCUN1D1CASP3 | |
| SCHEMBL20523304 | 0.88 | MDM4 (0.47) | EPHX2MDM4TP53CASP3MDM2 | |
| SCHEMBL20523302 | 0.88 | MDM4 (0.47) | EPHX2MDM4TP53CASP3MDM2 | |
| SCHEMBL29554589 | 0.83 | EPHX2 (0.39) | EPHX2MDM4TP53CASP3MDM2 | |
| SCHEMBL20522939 | 0.81 | MDM4 (0.49) | EPHX2MDM4TP53CASP3MDM2 | |
| SCHEMBL20522940 | 0.81 | MDM4 (0.49) | EPHX2MDM4TP53CASP3MDM2 | |
| SCHEMBL20526776 | 0.78 | MDM2 (0.49) | EPHX2MDM4TP53CASP3MDM2 | |
| SCHEMBL20526651 | 0.78 | MDM2 (0.53) | MDM4TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110740996-A | Covalent small molecule DCN1 inhibitors and methods of treatment using the same | 密执安大学评议会 | 2020-01-31 | — | — | CN | disclosed |