Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.51 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.51 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553010 | 0.88 | MTOR (0.73) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL30405609 | 0.86 | MTOR (0.55) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL20553492 | 0.86 | MTOR (0.59) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL30405139 | 0.86 | MTOR (0.59) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL20553464 | 0.85 | MTOR (0.61) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| Trifluoroacetic Acid SCHEMBL20552724 | 0.84 | MTOR (0.58) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| Trifluoroacetic Acid SCHEMBL29669770 | 0.84 | MTOR (0.58) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23157413 | 0.83 | MTOR (0.57) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23158102 | 0.82 | MTOR (0.57) | MTORHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23157490 | 0.82 | MTOR (0.57) | MTORHDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112368289-B | C26-linked rapamycin analogues as MTOR inhibitors | 锐新医药公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-115916194-A | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors | 锐新医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-112771054-A | C40-, C28-and C-32-linked rapamycin analogs as mTOR inhibitors | 锐新医药公司 | 2021-05-07 | — | — | CN | disclosed |
| CN-112368289-A | C26-linked rapamycin analogs as MTOR inhibitors | 锐新医药公司 | 2021-02-12 | — | — | CN | disclosed |
| CN-110770243-A | Rapamycin analogs as MTOR inhibitors | 锐新医药公司 | 2020-02-07 | — | — | CN | disclosed |