SCHEMBL28356306

SCHEMBL28356306

CS(=O)(=O)c1cncc(COc2nc(O[C@H]3CCc4c(-c5c(OCCNCCO)ccc(-c6ccccc6)c5Cl)cccc43)c(Cl)cc2CNCC(O)CC(=O)O)c1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 20/20 0.59
PDCD1 Q15116 17/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28356304 1.00 CD274 (0.59) CD274PDCD1
SCHEMBL28356190 0.90 CD274 (0.68) CD274PDCD1
SCHEMBL28356196 0.90 CD274 (0.68) CD274PDCD1
SCHEMBL20539503 0.90 CD274 (0.62) CD274PDCD1
SCHEMBL20539506 0.90 CD274 (0.62) CD274PDCD1
SCHEMBL23949441 0.87 CD274 (0.74) CD274PDCD1
SCHEMBL23949741 0.85 CD274 (0.67) CD274PDCD1
SCHEMBL23949204 0.82 CD274 (0.77) CD274PDCD1
SCHEMBL23961497 0.82 PDCD1 (0.64) CD274PDCD1
SCHEMBL20539378 0.81 CD274 (0.66) CD274PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110799509-A PD-1/PD-L1 inhibitors 吉利德科学公司 2020-02-14 CN disclosed