Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 15/20 | 0.57 |
| ▸ | KDR | P35968 | 11/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.57 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.57 |
| ▸ | CASK | O14936 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.57 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28353780 | 0.93 | RET (0.56) | RETKDRPIK3CDSRCTGFBR1 | |
| SCHEMBL21528193 | 0.86 | RET (0.63) | RETKDRPIK3CDSRCTGFBR1 | |
| SCHEMBL30404443 | 0.86 | RET (0.63) | RETKDRPIK3CDSRCTGFBR1 | |
| SCHEMBL26064027 | 0.85 | RET (0.56) | RETKDRPIK3CDSRCTGFBR1 | |
| SCHEMBL30405924 | 0.85 | RET (0.52) | RETKDRPIK3CDSRCTGFBR1 | |
| SCHEMBL28353223 | 0.85 | RET (0.47) | RETKDRPIK3CDSRCTGFBR1 | |
| SCHEMBL20552898 | 0.84 | RET (0.57) | RETKDRPIK3CDSRCTGFBR1 | |
| SCHEMBL12422357 | 0.84 | RET (0.65) | RETKDRPIK3CDSRCTGFBR1 | |
| Trifluoroacetic Acid SCHEMBL21528199 | 0.83 | RET (0.55) | RETKDRPIK3CDSRCTGFBR1 | |
| Trifluoroacetic Acid SCHEMBL29669754 | 0.83 | RET (0.55) | RETKDRPIK3CDSRCTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112368289-B | C26-linked rapamycin analogues as MTOR inhibitors | 锐新医药公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-112771054-A | C40-, C28-and C-32-linked rapamycin analogs as mTOR inhibitors | 锐新医药公司 | 2021-05-07 | — | — | CN | disclosed |
| CN-112368289-A | C26-linked rapamycin analogs as MTOR inhibitors | 锐新医药公司 | 2021-02-12 | — | — | CN | disclosed |
| CN-110770243-A | Rapamycin analogs as MTOR inhibitors | 锐新医药公司 | 2020-02-07 | — | — | CN | disclosed |