SCHEMBL2835910

SCHEMBL2835910

O=C(O)NCCCCc1cc(-c2ccc(Cl)cc2)no1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.64
HTT P42858 4/20 0.64
L3MBTL1 Q9Y468 4/20 0.64
ALDH1A1 P00352 2/20 0.64
JAK2 O60674 1/20 0.64
POLB P06746 2/20 0.58
LMNA P02545 3/20 0.55
NOTUM Q6P988 2/20 0.55
MEN1 O00255 6/20 0.48
KMT2A Q03164 6/20 0.48
MAPT P10636 4/20 0.48
RAB9A P51151 3/20 0.48
CYP1A2 P05177 3/20 0.48
CYP2C19 P33261 3/20 0.48
NPC1 O15118 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2D6 P10635 2/20 0.48
CYP2C9 P11712 2/20 0.48
GAA P10253 1/20 0.46
TDP1 Q9NUW8 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2838237 0.96 SMN1; SMN2 (0.65) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL2842157 0.89 NOTUM (0.51) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL2840193 0.85 NOTUM (0.52) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL11495864 0.83 POLB (0.78) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL2839518 0.82 HDAC6 (0.47) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL2410448 0.81 SMN1; SMN2 (0.55) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL2410803 0.78 SMN1; SMN2 (0.56) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL2412732 0.78 NOTUM (0.71) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL2840781 0.78 HDAC6 (0.47) SMN1; SMN2HTTL3MBTL1ALDH1A1JAK2
SCHEMBL2844564 0.78 NOTUM (0.55) L3MBTL1POLBNOTUMMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2251324-A1 HETEROARYL-ALKYLCARBAMATE COMPOUNDS AND THEIR USE AS INHIBITORS OF THE FAAH ENZYME Sanofi-Aventis (FR) 2010-11-17 EP disclosed
EP-1720829-B1 DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS SANOFI AVENTIS (FR) 2009-10-14 EP disclosed
EP-1720829-A1 DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS Sanofi-Aventis (FR) 2006-11-15 EP disclosed
WO-2005090292-A1 DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2005-09-29 WO disclosed