Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29887170 | 0.91 | TP53 (0.51) | TP53MAPTUSP30ABCB1ABCG2 | |
| SCHEMBL20552124 | 0.88 | MAPT (0.52) | TP53MAPTABCB1ABCG2HTT | |
| SCHEMBL20551540 | 0.84 | TP53 (0.50) | TP53MAPTUSP30ABCB1ABCG2 | |
| SCHEMBL21750810 | 0.84 | TP53 (0.50) | TP53MAPTUSP30ABCB1ABCG2 | |
| SCHEMBL21750686 | 0.76 | HTT (0.49) | MAPTUSP30HTTKDM4EMEN1 | |
| SCHEMBL20551893 | 0.76 | HTT (0.49) | MAPTUSP30HTTKDM4EMEN1 | |
| SCHEMBL20551736 | 0.76 | JAK2 (0.52) | TP53USP30HTTKDM4EMEN1 | |
| SCHEMBL20551970 | 0.75 | TP53 (0.51) | TP53MAPTABCB1ABCG2ABCC1 | |
| SCHEMBL20552141 | 0.74 | TP53 (0.50) | TP53MAPTABCB1ABCG2ABCC1 | |
| SCHEMBL20551138 | 0.73 | MAPT (0.64) | TP53MAPTABCB1ABCG2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279833-B | Trisubstituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders and cardiomyopathy | 意大利学院科技基金会 | 2024-04-16 | — | — | CN | disclosed |
| CN-110799505-B | Trisubstituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders and cardiomyopathy | 意大利学院科技基金会 | 2022-08-30 | — | — | CN | disclosed |
| CN-112279833-A | Tri-substituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders and cardiomyopathy | 意大利学院科技基金会 | 2021-01-29 | — | — | CN | disclosed |
| CN-110799505-A | Tri-substituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders and cardiomyopathy | 意大利学院科技基金会 | 2020-02-14 | — | — | CN | disclosed |