Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 16/20 | 0.70 |
| ▸ | CYSLTR1 | Q9Y271 | 16/20 | 0.70 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tipelukast SCHEMBL154898 | 0.85 | CYSLTR2 (0.78) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| Tipelukast SCHEMBL29359070 | 0.85 | CYSLTR2 (0.78) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9734038 | 0.83 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL21894565 | 0.82 | CYSLTR2 (0.61) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9623054 | 0.82 | CYSLTR2 (0.98) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9622269 | 0.82 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL10688316 | 0.82 | CYSLTR2 (1.00) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9622368 | 0.82 | CYSLTR2 (0.96) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9435407 | 0.82 | CYSLTR2 (0.79) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL10691639 | 0.82 | CYSLTR2 (0.86) | CYSLTR2CYSLTR1PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110840847-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-106163517-B | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2020-08-14 | — | — | CN | disclosed |
| CN-110840847-A | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases | 沃泰克斯药物股份有限公司 | 2020-02-28 | — | — | CN | disclosed |