Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18202189 | 0.91 | EGFR (0.47) | EGFRKCNH2 | |
| SCHEMBL19921275 | 0.84 | EGFR (0.43) | EGFRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL28378854 | 0.82 | EGFR (0.43) | EGFRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL18202284 | 0.80 | EGFR (0.47) | EGFRKCNH2 | |
| SCHEMBL19921265 | 0.79 | EGFR (0.41) | EGFRCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL19921278 | 0.78 | EGFR (0.41) | EGFRLCKGSK3BDYRK1A | |
| SCHEMBL18202285 | 0.78 | EGFR (0.63) | EGFRKCNH2 | |
| SCHEMBL18202166 | 0.77 | EGFR (0.60) | EGFRKCNH2 | |
| SCHEMBL21158687 | 0.77 | EGFR (0.45) | EGFR | |
| SCHEMBL18202318 | 0.77 | EGFR (0.52) | EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107973791-B | Fused or tricyclic aryl pyrimidine compounds as kinase inhibitors | 南京圣和药业股份有限公司 | 2020-04-07 | — | — | CN | disclosed |
| CN-107614503-B | Fused or tricyclic aryl pyrimidine compounds as kinase inhibitors | 广东众生药业股份有限公司 | 2020-03-10 | — | — | CN | disclosed |