Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.53 |
| ▸ | JAK2 | O60674 | 6/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28368160 | 0.91 | JAK3 (0.58) | JAK3JAK2TYK2JAK1TTK | |
| SCHEMBL21846883 | 0.89 | JAK3 (0.60) | JAK3JAK2TYK2JAK1TTK | |
| SCHEMBL28364470 | 0.89 | JAK3 (0.60) | JAK3JAK2TYK2JAK1TTK | |
| SCHEMBL29387805 | 0.89 | JAK3 (0.60) | JAK3JAK2TYK2JAK1TTK | |
| SCHEMBL21846872 | 0.85 | JAK3 (0.61) | JAK3JAK2TYK2JAK1EGFR | |
| SCHEMBL28367964 | 0.85 | JAK3 (0.61) | JAK3JAK2TYK2JAK1EGFR | |
| SCHEMBL28364445 | 0.82 | EGFR (0.54) | JAK3JAK2JAK1TTKEGFR | |
| SCHEMBL21846882 | 0.82 | JAK3 (0.65) | JAK3JAK2TYK2JAK1EGFR | |
| SCHEMBL29387594 | 0.82 | JAK3 (0.65) | JAK3JAK2TYK2JAK1EGFR | |
| SCHEMBL21846870 | 0.81 | JAK3 (0.65) | JAK3JAK2TYK2JAK1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110885331-A | Preparation and application of novel 6-amino-1H-pyrazolo [3, 4-d ] pyrimidine JAK kinase inhibitor | 中国药科大学 | 2020-03-17 | — | — | CN | claimed |
| CN-110885331-B | Preparation and application of 6-amino-1H-pyrazolo [3, 4-d ] pyrimidine JAK kinase inhibitor | 中国药科大学 | 2021-07-09 | — | — | CN | disclosed |
| CN-110885331-A | Preparation and application of novel 6-amino-1H-pyrazolo [3, 4-d ] pyrimidine JAK kinase inhibitor | 中国药科大学 | 2020-03-17 | — | — | CN | disclosed |