Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.57 |
| ▸ | FYN | P06241 | 5/20 | 0.47 |
| ▸ | RET | P07949 | 6/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29576182 | 1.00 | NTRK1 (0.57) | NTRK1FYNRETPIM1CCNT1 | |
| SCHEMBL28370573 | 0.89 | RET (0.46) | NTRK1FYNRETPIM1 | |
| SCHEMBL28365992 | 0.85 | RET (0.49) | NTRK1FYNRETPIM1 | |
| SCHEMBL16459776 | 0.83 | NTRK1 (0.70) | NTRK1FYNRETPIM1CCNT1 | |
| SCHEMBL28370717 | 0.82 | NTRK1 (0.41) | NTRK1FYNRETPIM1 | |
| SCHEMBL29575468 | 0.82 | NTRK1 (0.41) | NTRK1FYNRETPIM1 | |
| SCHEMBL28885398 | 0.81 | RET (0.43) | NTRK1FYNRETPIM1 | |
| SCHEMBL406313 | 0.81 | NTRK1 (0.68) | NTRK1FYNRETPIM1KDM5A | |
| SCHEMBL28370818 | 0.81 | NTRK1 (0.39) | NTRK1FYNRETPIM1 | |
| SCHEMBL401467 | 0.79 | NTRK1 (0.69) | NTRK1FYNRETKDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110734437-B | Pyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 南京烁慧医药科技有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-110734437-A | Pyrazolopyrimidine compounds, pharmaceutical compositions and uses thereof | 金秋 | 2020-01-31 | — | — | CN | disclosed |