Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 2/20 | 0.68 |
| ▸ | SYK | P43405 | 11/20 | 0.63 |
| ▸ | ABL1 | P00519 | 6/20 | 0.52 |
| ▸ | BCR | P11274 | 6/20 | 0.52 |
| ▸ | SRC | P12931 | 5/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | PRKCA | P17252 | 4/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | PRKACG | P22612 | 1/20 | 0.51 |
| ▸ | PRKACB | P22694 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | PRKCH | P24723 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28376607 | 0.93 | SYK (0.67) | NR4A1SYK | |
| SCHEMBL28371930 | 0.85 | NR4A1 (0.67) | NR4A1SYKABL1BCRSRC | |
| SCHEMBL28376014 | 0.85 | ABL1 (0.67) | NR4A1SYKABL1BCRSRC | |
| SCHEMBL28546947 | 0.84 | NR4A1 (0.66) | NR4A1SYKABL1BCRSRC | |
| SCHEMBL28377492 | 0.84 | NR4A1 (0.66) | NR4A1SYKABL1BCRSRC | |
| SCHEMBL28377494 | 0.83 | NR4A1 (0.83) | NR4A1SYKABL1BCRSRC | |
| SCHEMBL28541022 | 0.82 | NR4A1 (0.73) | NR4A1SYKABL1BCRSRC | |
| SCHEMBL28375921 | 0.82 | NR4A1 (0.63) | NR4A1SYKABL1BCRSRC | |
| SCHEMBL28376597 | 0.82 | NR4A1 (0.71) | NR4A1SYKABL1BCRSRC | |
| SCHEMBL28372279 | 0.81 | HDAC1 (0.72) | NR4A1SYKABL1BCRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107739368-B | N-substituted-5- ((4-substituted pyrimidine-2-yl) amino) indole derivatives, and preparation method and application thereof | 厦门大学 | 2020-02-14 | — | — | CN | disclosed |