Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.73 |
| ▸ | HRH2 | P25021 | 1/20 | 0.69 |
| ▸ | HRH1 | P35367 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28373270 | 1.00 | HRH3 (0.73) | HRH3HRH2HRH1MAOBKDM4E | |
| Bromide SCHEMBL28373269 | 1.00 | HRH3 (0.73) | HRH3HRH2HRH1MAOBKDM4E | |
| Bromide SCHEMBL28375560 | 1.00 | HRH3 (0.73) | HRH3HRH2HRH1MAOBKDM4E | |
| SCHEMBL4094656 | 0.99 | HRH3 (0.74) | HRH3HRH2HRH1MAOBKDM4E | |
| SCHEMBL4094659 | 0.99 | HRH3 (0.74) | HRH3HRH2HRH1MAOBKDM4E | |
| Hydrochloric Acid SCHEMBL27711403 | 0.98 | HRH3 (0.73) | HRH3HRH2HRH1MAOBKDM4E | |
| Hydrochloric Acid SCHEMBL4595640 | 0.98 | HRH3 (0.73) | HRH3HRH2HRH1MAOBKDM4E | |
| Hydrochloric Acid SCHEMBL20511918 | 0.98 | HRH3 (0.73) | HRH3HRH2HRH1MAOBKDM4E | |
| Hydrochloric Acid SCHEMBL20511915 | 0.98 | HRH3 (0.73) | HRH3HRH2HRH1MAOBKDM4E | |
| Hydrochloric Acid SCHEMBL20509654 | 0.97 | HRH3 (0.71) | HRH3HRH2HRH1MAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891570-A | Novel therapeutic uses of H3-ligands | 生物计划制药公司 | 2020-03-17 | — | — | CN | claimed |
| CN-110891570-A | Novel therapeutic uses of H3-ligands | 生物计划制药公司 | 2020-03-17 | — | — | CN | disclosed |