Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525698 | 1.00 | NR1H2 (0.55) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL20554188 | 0.97 | NR1H2 (0.55) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL18986940 | 0.93 | NR1H2 (0.58) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL18986938 | 0.93 | NR1H2 (0.58) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL10106246 | 0.93 | NR1H2 (0.58) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL28666005 | 0.93 | NR1H2 (0.58) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL23963745 | 0.91 | NR1H2 (0.60) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL14870523 | 0.91 | NR1H2 (0.60) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL21774419 | 0.91 | NR1H2 (0.60) | NR1H2HPGDEPHX1CHRM2CHRM1 | |
| SCHEMBL8256164 | 0.91 | NR1H2 (0.60) | NR1H2HPGDEPHX1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818704-A | Spiro-bridged ring compounds, pharmaceutical compositions thereof and uses thereof | 广州市恒诺康医药科技有限公司 | 2020-02-21 | — | — | CN | disclosed |