SCHEMBL2837675

SCHEMBL2837675

CNC(=O)c1c(-c2ccc(F)cc2)oc2cc(NCS(C)(=O)=O)c(OCCc3nccs3)cc12

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.41
CYP2C9 P11712 3/20 0.41
CYP2C19 P33261 3/20 0.41
KCNH2 Q12809 3/20 0.38
CYP2C8 P10632 2/20 0.38
NR1I2 O75469 1/20 0.38
CACNA1C Q13936 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2839295 0.93 CYP3A4 (0.40) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8
SCHEMBL2839489 0.86 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19KCNH2CACNA1C
SCHEMBL2834892 0.86 CYP3A4 (0.43) CYP3A4CYP2C9CYP2C19KCNH2CACNA1C
SCHEMBL2845137 0.86 NPC1 (0.44) CYP3A4CYP2C9CYP2C19
SCHEMBL2837676 0.85 CACNA1C (0.48) CYP3A4CYP2C9CYP2C19CACNA1C
SCHEMBL3549398 0.85 CYP3A4 (0.39) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8
SCHEMBL2840736 0.83 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19KCNH2CACNA1C
SCHEMBL2841399 0.83 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8
SCHEMBL2838862 0.83 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19KCNH2CACNA1C
SCHEMBL2845281 0.83 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4537315-B2 2010-09-01 JP claimed
EP-1581207-A4 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES VIROPHARMA INC (US) 2007-07-25 EP claimed
JP-2006510736-A 2006-03-30 JP claimed
EP-1581207-A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES Viropharma Incorporated (US) 2005-10-05 EP claimed
WO-2004041201-A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES VIROPHARMA INCORPORATED (US) 2004-05-21 WO claimed