Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10289556 | 0.83 | IDO1 (0.40) | IDO1TDO2HTTMEN1KMT2A | |
| SCHEMBL10290280 | 0.83 | BTK (0.39) | IGF1RBTKCCNA2CDK2CCNA1 | |
| SCHEMBL14925807 | 0.81 | CCNA2 (0.44) | IGF1RBTKCCNA2CDK2CCNA1 | |
| SCHEMBL10255802 | 0.81 | DDB1 (0.45) | IDO1TDO2BTKCCNA2CDK2 | |
| SCHEMBL10289837 | 0.80 | BTK (0.38) | IGF1RBTKCCNA2CDK2CCNA1 | |
| SCHEMBL14926097 | 0.78 | IGF1R (0.38) | IGF1RBTKCCNA2CDK2CCNA1 | |
| SCHEMBL30512276 | 0.76 | PIK3CA (0.42) | IDO1TDO2BTKUSP30 | |
| SCHEMBL10256055 | 0.76 | PIK3CA (0.42) | IDO1TDO2BTKUSP30 | |
| SCHEMBL30507867 | 0.75 | BTK (0.54) | IDO1TDO2BTKUSP30 | |
| SCHEMBL10256545 | 0.75 | BTK (0.44) | IDO1TDO2BTKUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818724-B | Pyridone and azapyridone compounds and methods of use | 吉利德康涅狄格有限公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-107253963-B | Pyridone and azapyridone compounds and methods of use | 吉利德康涅狄格有限公司 | 2020-04-14 | — | — | CN | disclosed |
| CN-110818724-A | Pyridone and azapyridone compounds and methods of use | 吉利德康涅狄格有限公司 | 2020-02-21 | — | — | CN | disclosed |