SCHEMBL28378608

SCHEMBL28378608

C1=CCC2CCC(c3ccccc3)OC2=C1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.37
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
ATM Q13315 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KDM4E B2RXH2 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
AR P10275 1/20 0.32
CYP19A1 P11511 1/20 0.32
MAOB P27338 1/20 0.32
HSD17B10 Q99714 1/20 0.32
SLC18A3 Q16572 1/20 0.31
SIGMAR1 Q99720 1/20 0.31
HSD11B1 P28845 2/20 0.30
AKR1C3 P42330 1/20 0.30
AKR1C1 Q04828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adenine SCHEMBL12545367 0.79 ABL1 (0.31)
SCHEMBL7089078 0.74
SCHEMBL5273172 0.72 SLC18A3 (0.31) SLC18A3SIGMAR1
SCHEMBL28266530 0.72 CA1 (0.30)
SCHEMBL25317454 0.71 SLC18A3 (0.33) TSHRALDH1A1KDM4EHSD17B10SLC18A3
SCHEMBL28508361 0.71 MAPT (0.36) SLC6A3ALDH1A1HPGDSMN1; SMN2KDM4E
SCHEMBL10608571 0.71
SCHEMBL28508359 0.71 MAOB (0.42) ALDH1A1KDM4EADORA3ARCYP19A1
SCHEMBL28571183 0.66 MAPT (0.42) TSHRSLC6A2SLC6A4SLC6A3KDM4E
SCHEMBL25333568 0.65 TSHR (0.50) TSHRSLC6A2SLC6A4SLC6A3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114616230-A Flavanoid compounds and their use in the treatment of chronic and acute pain 海洋生物技术与海洋资源有限公司 2022-06-10 CN claimed
CN-114616230-A Flavanoid compounds and their use in the treatment of chronic and acute pain 海洋生物技术与海洋资源有限公司 2022-06-10 CN disclosed
CN-111032051-A Use of coenzyme factors for activating ATP production in cells 泰拉强石株式会社 2020-04-17 CN disclosed