Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28383372 | 0.83 | IRAK4 (0.41) | KMT2AMAPTMEN1 | |
| SCHEMBL28378694 | 0.80 | CYP1A2 (0.53) | CYP1A2CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL28378607 | 0.79 | CSF1R (0.51) | CYP1A2CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL28383104 | 0.77 | CYP1A2 (0.58) | CYP1A2CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL28887709 | 0.77 | CSF1R (0.57) | CYP1A2CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL28382783 | 0.74 | CHEK1 (0.51) | — | |
| SCHEMBL28380087 | 0.71 | PIM1 (0.42) | GAAKMT2AALDH1A1MAPK10L3MBTL1 | |
| SCHEMBL28379245 | 0.70 | PIM1 (0.42) | CSF1RALDH1A1MAPK10L3MBTL1MAPT | |
| SCHEMBL20598571 | 0.70 | CYP1A2 (0.55) | CYP1A2CYP2C9CYP2C19GAAKMT2A | |
| SCHEMBL28387084 | 0.69 | CSF1R (0.48) | CYP1A2CYP2C9CYP2C19GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-A | Kinase inhibitors and methods of making and using | 里格尔药品股份有限公司 | 2020-04-17 | — | — | CN | disclosed |