Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 16/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14926113 | 0.90 | BTK (0.49) | BTK | |
| SCHEMBL29742101 | 0.90 | BTK (0.49) | BTK | |
| SCHEMBL29742108 | 0.87 | CCND1 (0.48) | BTKCDK4CCND1 | |
| SCHEMBL1392785 | 0.87 | CCND1 (0.48) | BTKCDK4CCND1 | |
| SCHEMBL24374839 | 0.86 | BTK (0.49) | BTKCCND1MAP3K12WNT1GSK3B | |
| SCHEMBL29925331 | 0.84 | BTK (0.52) | BTK | |
| SCHEMBL1392995 | 0.84 | BTK (0.52) | BTK | |
| SCHEMBL28379157 | 0.82 | DDB1 (0.46) | BTKCDK4CCND1 | |
| SCHEMBL14926053 | 0.82 | LRRK2 (0.37) | BTKLRRK2MAP3K12WNT1GSK3B | |
| SCHEMBL609854 | 0.81 | BTK (0.46) | BTKLRRK2CDK4CCND1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818724-B | Pyridone and azapyridone compounds and methods of use | 吉利德康涅狄格有限公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-107253963-B | Pyridone and azapyridone compounds and methods of use | 吉利德康涅狄格有限公司 | 2020-04-14 | — | — | CN | disclosed |
| CN-110818724-A | Pyridone and azapyridone compounds and methods of use | 吉利德康涅狄格有限公司 | 2020-02-21 | — | — | CN | disclosed |