Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28383448 | 0.93 | EGFR (0.42) | MAP4K1EGFRFGFR1KDRFGFR2 | |
| SCHEMBL28384578 | 0.91 | FGFR1 (0.45) | MAP4K1EGFRFGFR1KDRFGFR2 | |
| SCHEMBL28384456 | 0.91 | FGFR1 (0.45) | MAP4K1EGFRFGFR1KDRFGFR2 | |
| SCHEMBL28388469 | 0.91 | FGFR1 (0.44) | EGFRFGFR1KDRFGFR2JAK2 | |
| SCHEMBL28385510 | 0.91 | FGFR1 (0.44) | EGFRFGFR1KDRFGFR2JAK2 | |
| SCHEMBL28887739 | 0.90 | EGFR (0.52) | EGFRFGFR1KDRFGFR2JAK2 | |
| SCHEMBL28383229 | 0.90 | MAP3K5 (0.36) | MAP4K1MAP3K5 | |
| SCHEMBL28382516 | 0.87 | MAPK8 (0.43) | EGFRFGFR1KDRFGFR2 | |
| SCHEMBL28382390 | 0.86 | EGFR (0.49) | EGFR | |
| SCHEMBL28070382 | 0.85 | TTK (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | claimed |
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111285813-A | Chemical entities, compositions, and methods | 润新生物公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | disclosed |