SCHEMBL2839136

SCHEMBL2839136

CN(c1cc2oc(-c3ccc(F)cc3)c(C(=O)O)c2cc1OCc1ccc(F)c(F)c1)S(C)(=O)=O

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ANO1 Q5XXA6 15/20 0.59
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
CYP19A1 P11511 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5488888 0.91 CYP3A4 (0.54) CYP3A4CYP2C9CYP2C19
SCHEMBL2841366 0.84 ANO1 (0.48) ANO1
SCHEMBL2871361 0.84 ANO1 (0.46) ANO1
SCHEMBL2864345 0.84 ANO1 (0.46) ANO1
SCHEMBL2841448 0.83 CYP3A4 (0.51) ANO1CYP3A4CYP2C9CYP2C19
SCHEMBL2836792 0.82 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19
SCHEMBL2841511 0.81 CACNA1C (0.50)
SCHEMBL2841607 0.81 CYP3A4 (0.50) CYP3A4CYP2C9CYP2C19
SCHEMBL2842402 0.80 ANO1 (0.57) ANO1CYP3A4CYP2C9CYP2C19
SCHEMBL5260010 0.80 ANO1 (0.48) ANO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4537315-B2 2010-09-01 JP claimed
EP-1581207-A4 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES VIROPHARMA INC (US) 2007-07-25 EP claimed
JP-2006510736-A 2006-03-30 JP claimed
EP-1581207-A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES Viropharma Incorporated (US) 2005-10-05 EP claimed
WO-2004041201-A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES VIROPHARMA INCORPORATED (US) 2004-05-21 WO claimed