Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 8/20 | 0.40 |
| ▸ | ITK | Q08881 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 6/20 | 0.38 |
| ▸ | CCNH | P51946 | 6/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28382516 | 0.92 | MAPK8 (0.43) | MAPK8MAPK9MAPK10IRAK1EGFR | |
| SCHEMBL28384166 | 0.91 | JAK3 (0.38) | JAK3 | |
| SCHEMBL28387903 | 0.91 | JAK3 (0.38) | JAK3 | |
| SCHEMBL28383193 | 0.89 | MAPK8 (0.38) | MAPK8MAPK9MAPK10IRAK1EGFR | |
| SCHEMBL28382401 | 0.88 | FGFR1 (0.42) | EGFRITKJAK3 | |
| SCHEMBL28383229 | 0.87 | MAP3K5 (0.36) | — | |
| SCHEMBL28394086 | 0.87 | FGFR1 (0.36) | EGFR | |
| SCHEMBL28388765 | 0.87 | FGFR1 (0.36) | EGFR | |
| SCHEMBL28383280 | 0.85 | — | — | |
| SCHEMBL28388469 | 0.82 | FGFR1 (0.44) | EGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | claimed |
| CN-109851617-B | Chemical entities, compositions, and methods | 润新生物公司 | 2022-08-16 | — | — | CN | disclosed |
| CN-111285813-A | Chemical entities, compositions, and methods | 润新生物公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-105682661-B | Certain chemical entities, compositions, and methods | 润新生物公司 | 2020-03-27 | — | — | CN | disclosed |