SCHEMBL28397264

SCHEMBL28397264

O=C(O)c1c(Cl)sc2cncn12

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 20/20 0.50
TDO2 P48775 19/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20743924 0.79 IDO1 (0.47) IDO1TDO2
SCHEMBL28399085 0.79 IDO1 (0.52) IDO1TDO2
SCHEMBL20743971 0.77 MAPK1 (0.41) IDO1TDO2
SCHEMBL28401002 0.76 IDO1 (0.56) IDO1TDO2
SCHEMBL28394123 0.76 IDO1 (0.51) IDO1TDO2
SCHEMBL28394587 0.74 IDO1 (0.56) IDO1TDO2
SCHEMBL28396343 0.73 IDO1 (0.52) IDO1TDO2
SCHEMBL28442115 0.72 IDO1 (0.59) IDO1TDO2
SCHEMBL20743966 0.71 IDO1 (0.55) IDO1TDO2
SCHEMBL20743967 0.71 IDO1 (0.55) IDO1TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110997682-A Inhibitors of indoleamine 2, 3-dioxygenase and/or tryptophan 2, 3-dioxygenase 爱杜西亚药品有限公司 2020-04-10 CN disclosed