SCHEMBL28397618

SCHEMBL28397618

C=CC(=O)Nc1cccc(Nc2nc(N)nc(Nc3ccc(Oc4ccccc4)cc3)n2)c1

nearest known ligand 0.68

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
EGFR P00533 15/20 0.68
BTK Q06187 12/20 0.68
KCNH2 Q12809 1/20 0.60
TGM2 P21980 1/20 0.58
ITK Q08881 4/20 0.55
ERBB2 P04626 2/20 0.54
JAK3 P52333 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30423688 1.00 EGFR (0.68) EGFRBTKKCNH2TGM2ITK
SCHEMBL30423151 0.89 EGFR (0.68) EGFRBTKKCNH2TGM2ITK
SCHEMBL28406585 0.89 EGFR (0.68) EGFRBTKKCNH2TGM2ITK
SCHEMBL28400978 0.88 EGFR (0.75) EGFRBTKKCNH2TGM2ITK
SCHEMBL30423295 0.88 EGFR (0.75) EGFRBTKKCNH2TGM2ITK
SCHEMBL2346314 0.81 EGFR (1.00) EGFRBTKITKJAK3
SCHEMBL13165513 0.81 EGFR (0.86) EGFRBTKITKJAK3
SCHEMBL691113 0.81 EGFR (0.67) EGFRBTKKCNH2TGM2ITK
SCHEMBL30423079 0.80 EGFR (0.53) EGFRBTKITK
SCHEMBL28397623 0.80 EGFR (0.53) EGFRBTKITK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057021-B S-triazine compound, preparation method and application thereof 中国药科大学 2023-05-23 CN claimed
CN-111057021-A S-triazine compound and its preparing method and use 中国药科大学 2020-04-24 CN claimed
CN-111057021-B S-triazine compound, preparation method and application thereof 中国药科大学 2023-05-23 CN disclosed
CN-111057021-A S-triazine compound and its preparing method and use 中国药科大学 2020-04-24 CN disclosed