Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | QDPR | P09417 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25217174 | 0.64 | HTR2C (1.00) | HTR2CSIGMAR1QDPRHTR6HTR2A | |
| SCHEMBL21246808 | 0.64 | HTR2C (0.38) | HTR2CSIGMAR1QDPRHTR6HTR2A | |
| SCHEMBL24402613 | 0.62 | — | — | |
| SCHEMBL1199051 | 0.61 | HTR2C (1.00) | HTR2CSIGMAR1QDPRHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL28666550 | 0.61 | HTR2C (0.47) | HTR2CSIGMAR1QDPRHTR6HRH3 | |
| SCHEMBL4790160 | 0.61 | HTR2C (0.61) | HTR2CSIGMAR1QDPRHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL20292040 | 0.60 | HTR2C (0.42) | HTR2CSIGMAR1QDPRHTR6HTR2A | |
| SCHEMBL28506378 | 0.60 | HTR2C (0.60) | HTR2CSIGMAR1QDPRHTR6HTR2A | |
| SCHEMBL3666854 | 0.60 | HTR2C (0.38) | HTR2CSIGMAR1QDPRHTR6HTR2A | |
| Hydrochloric Acid SCHEMBL7290341 | 0.60 | HTR2C (0.67) | HTR2CSIGMAR1QDPRHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115710266-A | Pyridopyrimidine derivative, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-111094289-B | Pyridopyrimidine derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-113082224-A | Pyridopyrimidine derivative conjugate, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2021-07-09 | — | — | CN | disclosed |
| CN-111094289-A | Pyridopyrimidine derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2020-05-01 | — | — | CN | disclosed |