Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.75 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.75 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.75 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.75 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Aminoquinazoline SCHEMBL28181385 | 0.89 | PI4KA (0.95) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL29363315 | 0.87 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL31377585 | 0.87 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL142513 | 0.87 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| SCHEMBL10970430 | 0.85 | MAP4K4 (0.59) | PI4KAPI4K2BPI4K2API4KBKDR | |
| 4-Aminoquinazoline SCHEMBL2521546 | 0.85 | PI4KA (0.95) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL29631400 | 0.85 | PI4KA (0.95) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL29618413 | 0.85 | PI4KA (0.95) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL29723576 | 0.85 | PI4KA (0.95) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL4171913 | 0.85 | PI4KA (0.95) | PI4KAPI4K2BPI4K2API4KBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111039878-B | 4-aminoquinazoline phenyl ether compound and application thereof | 青岛科技大学 | 2022-06-17 | — | — | CN | claimed |
| CN-111039878-A | 4-aminoquinazoline phenyl ether compound and application thereof | 青岛科技大学 | 2020-04-21 | — | — | CN | claimed |
| CN-111039878-B | 4-aminoquinazoline phenyl ether compound and application thereof | 青岛科技大学 | 2022-06-17 | — | — | CN | disclosed |
| CN-111039878-B | 4-aminoquinazoline phenyl ether compound and application thereof | 青岛科技大学 | 2022-06-17 | — | — | CN | disclosed |
| CN-111039878-A | 4-aminoquinazoline phenyl ether compound and application thereof | 青岛科技大学 | 2020-04-21 | — | — | CN | disclosed |
| CN-111039878-A | 4-aminoquinazoline phenyl ether compound and application thereof | 青岛科技大学 | 2020-04-21 | — | — | CN | disclosed |