Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13700790 | 0.84 | TDP1 (0.56) | TDP1MEN1GAAKMT2AMAOA | |
| SCHEMBL19935593 | 0.83 | TDP1 (0.42) | TDP1MEN1GAAKMT2ACTSK | |
| SCHEMBL18124759 | 0.83 | TDP1 (0.42) | TDP1MEN1GAAKMT2ACTSK | |
| SCHEMBL18125237 | 0.83 | TDP1 (0.42) | TDP1MEN1GAAKMT2ACTSK | |
| SCHEMBL5772332 | 0.83 | MEN1 (0.40) | TDP1MEN1GAAKMT2ATSHR | |
| SCHEMBL55502 | 0.82 | TDP1 (0.46) | TDP1MEN1GAAKMT2ACTSK | |
| SCHEMBL18124813 | 0.81 | TDP1 (0.41) | TDP1MEN1GAAKMT2ACTSK | |
| SCHEMBL19520047 | 0.81 | TDP1 (0.41) | TDP1MEN1GAAKMT2ACTSK | |
| SCHEMBL7886169 | 0.80 | MEN1 (0.41) | TDP1MEN1GAAKMT2ATSHR | |
| SCHEMBL19997953 | 0.79 | CA1 (0.41) | TDP1MEN1GAAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |