Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 16/20 | 1.00 |
| ▸ | ESR1 | P03372 | 14/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 12/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.73 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.73 |
| ▸ | ESRRG | P62508 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22995790 | 1.00 | CYP19A1 (1.00) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL24302096 | 1.00 | CYP19A1 (1.00) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL906293 | 0.95 | ESR1 (0.90) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL9098766 | 0.95 | ESR1 (0.90) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL9098770 | 0.95 | ESR1 (0.90) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL21478102 | 0.90 | ESR1 (0.81) | CYP19A1ESR1ESR2CYP3A4CYP1A2 | |
| SCHEMBL5738276 | 0.88 | ESR1 (0.79) | CYP19A1ESR1ESR2ESRRGLMNA | |
| SCHEMBL8362672 | 0.88 | ESR1 (0.79) | CYP19A1ESR1ESR2ESRRGLMNA | |
| SCHEMBL8362668 | 0.88 | ESR1 (0.79) | CYP19A1ESR1ESR2ESRRGLMNA | |
| SCHEMBL5738281 | 0.88 | ESR1 (0.79) | CYP19A1ESR1ESR2ESRRGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111205282-B | ER protein modulators and uses thereof | 上海科技大学 | 2023-12-01 | — | — | CN | disclosed |
| CN-116239566-A | E3 ubiquitin ligase ligand compound, protein degradation agent developed based on ligand compound and application thereof | 标新生物医药科技(上海)有限公司 | 2023-06-09 | — | — | CN | disclosed |
| CN-110357889-B | Protein degradation targeting compound, anti-tumor application thereof, intermediate thereof and application of intermediate | 上海科技大学 | 2022-03-15 | — | — | CN | disclosed |
| CN-111205282-A | ER protein modulators and uses thereof | 上海科技大学 | 2020-05-29 | — | — | CN | disclosed |