Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28407980 | 0.87 | MAPT (0.37) | IRAK4 | |
| SCHEMBL28404453 | 0.80 | IRAK4 (0.44) | IRAK4 | |
| SCHEMBL28405615 | 0.79 | IRAK4 (0.41) | IRAK4 | |
| SCHEMBL23110713 | 0.78 | IRAK4 (0.54) | IRAK4 | |
| SCHEMBL30090077 | 0.78 | IRAK4 (0.54) | IRAK4 | |
| SCHEMBL20594546 | 0.77 | SMARCA2 (0.45) | IRAK4 | |
| SCHEMBL20594568 | 0.75 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL19030314 | 0.73 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL19030946 | 0.73 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL19046148 | 0.72 | IRAK4 (0.51) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111094292-A | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2020-05-01 | — | — | CN | disclosed |