Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334624 | 1.00 | TRPV1 (0.53) | TRPV1HRH1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2846899 | 0.98 | SMN1; SMN2 (0.50) | TRPV1HRH1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2844665 | 0.93 | KDM4E (0.54) | CYP2C9CYP2C19SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL334426 | 0.85 | SMN1; SMN2 (0.63) | ALDH1A1SMN1; SMN2RAB9ANPC1NAMPT | |
| SCHEMBL8671157 | 0.85 | KDM4E (0.53) | TRPV1HRH1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL893485 | 0.84 | TRPV1 (0.72) | TRPV1ALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2021336 | 0.84 | TRPV1 (0.72) | TRPV1ALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15861957 | 0.84 | TRPV1 (0.72) | TRPV1ALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2021996 | 0.84 | TRPV1 (0.72) | TRPV1ALDH1A1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2024980 | 0.84 | TRPV1 (0.72) | TRPV1ALDH1A1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251324-A1 | HETEROARYL-ALKYLCARBAMATE COMPOUNDS AND THEIR USE AS INHIBITORS OF THE FAAH ENZYME | Sanofi-Aventis (FR) | 2010-11-17 | — | — | EP | disclosed |
| EP-1720829-B1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2009-10-14 | — | — | EP | disclosed |