Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23782113 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL18661287 | 0.83 | CHRM2 (0.51) | SMN1; SMN2ALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL15767458 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1TP53CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL23782091 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2310462 | 0.82 | HSD17B10 (0.44) | SMN1; SMN2ALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL8314437 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2849211 | 0.80 | PDE4A (0.38) | CYP3A4CYP2D6HTR2ACACNA1HNQO2 | |
| SCHEMBL10765842 | 0.80 | POLB (0.45) | ALDH1A1CBFBPOLB | |
| SCHEMBL2845899 | 0.78 | POLB (0.46) | POLBMAOBADORA2ASLC40A1CACNA1H | |
| SCHEMBL15767238 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1TP53CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202885-B2 | Bridged six-membered ring compounds | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-06-19 | — | — | US | disclosed |
| US-20100130545-A1 | BRIDGED SIX-MEMBERED RING COMPOUNDS | IDORSIA PHARMACEUTICALS LTD (CH) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130545-A1 | BRIDGED SIX-MEMBERED RING COMPOUNDS | CACNA1E, CACNA1B, CACNA1A | SMN1; SMN2 2919/4885ALDH1A1 1834/4885TP53 4168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.