Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846657 | 0.85 | KCNH2 (0.54) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2847499 | 0.84 | KCNH2 (0.53) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL7804117 | 0.82 | KCNH2 (0.51) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2849631 | 0.79 | KCNH2 (0.42) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2847912 | 0.76 | KCNH2 (0.50) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2847508 | 0.76 | KCNH2 (0.39) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL7804800 | 0.74 | KCNH2 (0.37) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846415 | 0.73 | KCNH2 (0.73) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2846217 | 0.71 | PSEN1 (0.77) | KCNH2PTGS1PTGS2PSEN1PSEN2 | |
| SCHEMBL2849624 | 0.71 | PSEN1 (0.77) | KCNH2PTGS1PTGS2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138901-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE | BIOGEN IDEC MA INC (US) | 2010-12-02 | — | — | WO | disclosed |