Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 1.00 |
| ▸ | JAK2 | O60674 | 16/20 | 1.00 |
| ▸ | JAK3 | P52333 | 5/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | BTK | Q06187 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20183293 | 1.00 | JAK1 (1.00) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL2316849 | 0.88 | JAK2 (0.79) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL3679052 | 0.88 | JAK2 (0.79) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL20183435 | 0.86 | JAK1 (1.00) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL20183432 | 0.86 | JAK1 (1.00) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL21400287 | 0.84 | JAK1 (0.73) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL7494320 | 0.83 | JAK2 (0.71) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL20183401 | 0.83 | JAK1 (0.76) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL20183396 | 0.83 | JAK1 (0.76) | JAK1JAK2JAK3TYK2KCNH2 | |
| SCHEMBL21334304 | 0.82 | JAK1 (0.80) | JAK1JAK2JAK3TYK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137608-B | Janus kinase 1 selective inhibitor and pharmaceutical application thereof | 阳智化学（株） | 2020-06-19 | — | — | CN | claimed |
| CN-108137608-B | Janus kinase 1 selective inhibitor and pharmaceutical application thereof | 阳智化学（株） | 2020-06-19 | — | — | CN | disclosed |