Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29403353 | 1.00 | GAA (0.41) | GAAKDM4EALDH1A1MAPTTHRB | |
| SCHEMBL19451468 | 1.00 | GAA (0.41) | GAAKDM4EALDH1A1MAPTTHRB | |
| SCHEMBL22121273 | 0.90 | GAA (0.48) | GAAKDM4EALDH1A1MAPTTHRB | |
| SCHEMBL22932803 | 0.86 | STING1 (0.44) | GAAKDM4EALDH1A1BRD4HDAC1 | |
| SCHEMBL29405983 | 0.84 | KMT2A (0.52) | GAAKDM4EALDH1A1MAPTHTT | |
| SCHEMBL28419206 | 0.84 | KMT2A (0.52) | GAAKDM4EALDH1A1MAPTHTT | |
| SCHEMBL19451471 | 0.84 | KMT2A (0.52) | GAAKDM4EALDH1A1MAPTHTT | |
| SCHEMBL22121490 | 0.83 | GAA (0.51) | GAAKDM4EALDH1A1MAPTTHRB | |
| SCHEMBL29619906 | 0.82 | BRD4 (0.52) | GAAKDM4EALDH1A1MAPTPTGER4 | |
| SCHEMBL19448912 | 0.82 | BRD4 (0.52) | GAAKDM4EALDH1A1MAPTPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111417630-B | Modulators of interferon gene stimulating factor (STING) | 葛兰素史克知识产权开发有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-113549110-A | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-109608443-B | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-110016025-B | Immunomodulator | 成都先导药物开发股份有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-109071514-B | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-111417630-A | Modulators of interferon gene stimulating factor (STING) | 葛兰素史克知识产权开发有限公司 | 2020-07-14 | — | — | CN | disclosed |
| CN-111194214-A | Methods of administering STING agonists | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-05-22 | — | — | CN | disclosed |