Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 13/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28414568 | 0.92 | BTK (0.56) | RETRIPK1BTKFYNPIK3CD | |
| SCHEMBL28409178 | 0.89 | BTK (0.51) | RIPK1BTKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28890944 | 0.88 | BTK (0.56) | RIPK1BTKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28407414 | 0.87 | BTK (0.49) | BTKFYNPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28414191 | 0.84 | BTK (0.50) | RETBTKFYNPIK3CDPIK3CA | |
| SCHEMBL28403789 | 0.84 | BTK (0.50) | BTKFYNPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28407036 | 0.82 | BTK (0.51) | RIPK1BTKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL28409197 | 0.81 | BTK (0.54) | BTKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28407416 | 0.80 | BTK (0.53) | BTKPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL28409184 | 0.80 | BTK (0.60) | RETRIPK1BTKFYNEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111196813-B | 1,3, 4-trisubstituted pyrazolopyrimidine compound as well as preparation method and application thereof | 山东大学 | 2021-10-26 | — | — | CN | disclosed |
| CN-111196813-A | 1,3, 4-trisubstituted pyrazolopyrimidine compound as well as preparation method and application thereof | 山东大学 | 2020-05-26 | — | — | CN | disclosed |