Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28414150 | 0.84 | FGFR1 (0.47) | SLC6A4SLC6A3POLBCNR2PDK2 | |
| SCHEMBL28414986 | 0.82 | EGFR (0.50) | EGFRSLC6A3LMNAPOLBXDH | |
| SCHEMBL28412012 | 0.82 | EGFR (0.50) | EGFRLMNAPOLBXDHGAA | |
| SCHEMBL28417774 | 0.82 | EGFR (0.50) | EGFRSLC6A4SLC6A3LMNAPOLB | |
| SCHEMBL31418356 | 0.81 | TSHR (0.53) | EGFRSLC6A3LMNAKDM4ETSHR | |
| SCHEMBL6851115 | 0.81 | TPMT (0.52) | LMNAPOLBKDM4ETDP1CNR2 | |
| SCHEMBL6082886 | 0.80 | EGFR (0.57) | EGFRXDHGAAPDK2TSHR | |
| SCHEMBL2437425 | 0.78 | TSHR (0.49) | EGFRSLC6A4SLC6A3LMNAPOLB | |
| SCHEMBL2409870 | 0.78 | TSHR (0.49) | EGFRSLC6A4SLC6A3LMNAPOLB | |
| SCHEMBL2035147 | 0.78 | EGFR (0.71) | EGFRSLC6A4SLC6A3LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108101845-B | Preparation method of eltrombopag | 苏州科伦药物研究有限公司 | 2020-05-15 | — | — | CN | disclosed |