Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 20/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19451551 | 1.00 | STING1 (0.63) | STING1CYP3A4TBK1 | |
| SCHEMBL29689433 | 1.00 | STING1 (0.63) | STING1CYP3A4TBK1 | |
| SCHEMBL28413976 | 0.96 | STING1 (0.68) | STING1CYP3A4TBK1 | |
| SCHEMBL19451769 | 0.96 | STING1 (0.68) | STING1CYP3A4TBK1 | |
| SCHEMBL29626027 | 0.96 | STING1 (0.68) | STING1CYP3A4TBK1 | |
| SCHEMBL29689199 | 0.92 | STING1 (0.76) | STING1CYP3A4 | |
| SCHEMBL20066424 | 0.91 | STING1 (0.69) | STING1CYP3A4TBK1 | |
| SCHEMBL27204003 | 0.90 | STING1 (0.76) | STING1CYP3A4 | |
| SCHEMBL27204043 | 0.90 | STING1 (0.76) | STING1CYP3A4 | |
| SCHEMBL20876384 | 0.89 | STING1 (0.60) | STING1CYP3A4TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114585623-A | Bis [ N- ((5-carbamoyl) -1H-benzo [ d ] imidazol-2-yl) pyrazole-5-carboxamide ] derivatives and related compounds as STING (interferon gene stimulator) agonists for the treatment of cancer | 梅尔莎纳医疗公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-113549110-A | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-109608443-B | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-109071514-B | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-111194214-A | Methods of administering STING agonists | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-05-22 | — | — | CN | disclosed |