Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.70 |
| ▸ | RET | P07949 | 3/20 | 0.70 |
| ▸ | SRC | P12931 | 3/20 | 0.70 |
| ▸ | JAK2 | O60674 | 2/20 | 0.70 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.70 |
| ▸ | CDK1 | P06493 | 2/20 | 0.70 |
| ▸ | ROS1 | P08922 | 2/20 | 0.70 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.70 |
| ▸ | CDK2 | P24941 | 2/20 | 0.70 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.70 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.70 |
| ▸ | CLK2 | P49760 | 2/20 | 0.70 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.70 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.70 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.70 |
| ▸ | CDC7 | O00311 | 1/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17235877 | 1.00 | KDR (0.70) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL4826075 | 0.92 | KDR (0.78) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL4826083 | 0.92 | KDR (0.78) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL17911543 | 0.92 | KDR (0.78) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL24096480 | 0.89 | JAK2 (0.86) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL29999054 | 0.89 | JAK2 (0.86) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL22243320 | 0.86 | KDR (0.87) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL401336 | 0.83 | KDR (0.77) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL20533742 | 0.83 | RET (0.68) | KDRRETSRCJAK2DYRK3 | |
| SCHEMBL29590269 | 0.83 | SRC (0.77) | KDRRETSRCJAK2DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108295073-B | Polyfluoro compounds as bruton's tyrosine kinase inhibitors | 浙江导明医药科技有限公司 | 2020-06-16 | — | — | CN | disclosed |