Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.67 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL852 | 1.00 | — | — | |
| Bicarbonate SCHEMBL2351948 | 1.00 | CA4 (0.67) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1332143 | 1.00 | — | — | |
| Bicarbonate SCHEMBL2275798 | 1.00 | CA4 (0.67) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL23246204 | 0.94 | — | — | |
| Bicarbonate SCHEMBL7895320 | 0.94 | — | — | |
| Bicarbonate SCHEMBL991844 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA | |
| Bicarbonate SCHEMBL1603055 | 0.94 | — | — | |
| Bicarbonate SCHEMBL20917373 | 0.94 | — | — | |
| Bicarbonate SCHEMBL9053906 | 0.94 | CA4 (0.60) | CA4FAHD1CA1MEN1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111518479-A | Water-resistant high-strength inorganic silicate adhesive and preparation method thereof | 胡剑安 | 2020-08-11 | — | — | CN | disclosed |
| CN-110527247-B | Double-network polyether-ether-ketone composite material and preparation method and application thereof | 吉林大学 | 2020-07-03 | — | — | CN | disclosed |