Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | PIM1 | P11309 | 3/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28423622 | 0.88 | MAPT (0.67) | MAPTTP53LMNATSHRMAPK1 | |
| SCHEMBL28426697 | 0.86 | MEN1 (0.60) | MAPTTP53LMNATSHRMAPK1 | |
| SCHEMBL13405543 | 0.84 | MAPT (0.55) | MAPTTP53LMNATSHRMAPK1 | |
| SCHEMBL28421857 | 0.82 | SMN1; SMN2 (0.65) | MAPTTP53L3MBTL1SMN1; SMN2POLB | |
| SCHEMBL28419621 | 0.80 | POLB (0.49) | MAPTTP53SMN1; SMN2POLBPIM1 | |
| SCHEMBL28424900 | 0.80 | MEN1 (0.54) | MAPTTP53L3MBTL1SMN1; SMN2POLB | |
| SCHEMBL28429344 | 0.79 | TP53 (0.67) | MAPTTP53LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL13405572 | 0.76 | MAPT (0.53) | MAPTTP53LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL28427773 | 0.75 | MAPT (0.53) | MAPTLMNAMAPK1SMN1; SMN2POLB | |
| SCHEMBL28420937 | 0.75 | POLB (0.49) | MAPTTP53LMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110981819-B | Quinoxaline signal channel inhibitor and preparation method and application thereof | 广西师范大学 | 2022-07-01 | — | — | CN | disclosed |
| CN-110981819-A | Quinoxaline signal channel inhibitor and preparation method and application thereof | 广西师范大学 | 2020-04-10 | — | — | CN | disclosed |