SCHEMBL28423907

SCHEMBL28423907

O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccccc1N=Nc1c(F)cccc1F

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 19/20 0.59
KDR P35968 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28423905 1.00 TRPV1 (0.59) TRPV1KDR
SCHEMBL30681187 1.00 TRPV1 (0.59) TRPV1KDR
SCHEMBL30681179 0.86 TRPV1 (0.62) TRPV1KDR
SCHEMBL30681214 0.86 TRPV1 (0.62) TRPV1KDR
SCHEMBL28425517 0.85 KDR (0.64) TRPV1KDR
SCHEMBL28425515 0.85 KDR (0.64) TRPV1KDR
SCHEMBL28416007 0.84 KDR (0.62) TRPV1KDR
SCHEMBL28416006 0.84 KDR (0.62) TRPV1KDR
SCHEMBL6430968 0.82 KDR (0.70) TRPV1KDR
SCHEMBL28415912 0.82 TRPV1 (0.62) TRPV1KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111217722-B Azo aryl urea derivative, and preparation method and application thereof 华东理工大学 2024-01-02 CN disclosed
CN-111217722-A Azo aryl urea derivative and preparation method and application thereof 华东理工大学 2020-06-02 CN disclosed