Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28419107 | 0.85 | IRAK4 (0.50) | FLT3IRAK4CCNT1CCNKCCNE1 | |
| SCHEMBL28418443 | 0.83 | IRAK4 (0.49) | FLT3IRAK4CCNT1CCNKCCNE1 | |
| SCHEMBL28420343 | 0.83 | IRAK4 (0.49) | FLT3IRAK4CCNT1CCNKCCNE1 | |
| SCHEMBL28425526 | 0.83 | KMT2A (0.52) | FLT3IRAK4CCNT1CCNKCCNE1 | |
| SCHEMBL28416018 | 0.83 | FLT3 (0.45) | FLT3IRAK4CCNT1CCNKCCNE1 | |
| SCHEMBL28424661 | 0.81 | IRAK4 (0.52) | FLT3IRAK4CCNT1CCNKCCNE1 | |
| SCHEMBL28418539 | 0.80 | IRAK4 (0.51) | FLT3IRAK4 | |
| SCHEMBL28422780 | 0.80 | DDB1 (0.51) | FLT3IRAK4CCNT1CCNKCCNE1 | |
| SCHEMBL28418704 | 0.80 | FLT3 (0.46) | FLT3IRAK4CCNT1CCNKCCNE1 | |
| SCHEMBL28418400 | 0.80 | FLT3 (0.48) | FLT3IRAK4CCNT1CCNKCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111217816-B | FLT3 kinase inhibitor and preparation and application thereof | 中国科学院上海药物研究所 | 2022-08-16 | — | — | CN | disclosed |
| CN-111217816-A | FLT3 kinase inhibitor and preparation and application thereof | 中国科学院上海药物研究所 | 2020-06-02 | — | — | CN | disclosed |