Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28420302 | 0.95 | CHRM1 (0.46) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Bicarbonate SCHEMBL28420339 | 0.95 | CHRM1 (0.50) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Bicarbonate SCHEMBL28428215 | 0.92 | CHRM1 (0.48) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Butane SCHEMBL28430205 | 0.92 | CHRM1 (0.48) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Isobutane SCHEMBL28422639 | 0.92 | CHRM1 (0.48) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Bicarbonate SCHEMBL9490608 | 0.92 | HDAC1 (0.52) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Bicarbonate SCHEMBL14245001 | 0.92 | HDAC1 (0.52) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Bicarbonate SCHEMBL7424110 | 0.92 | HDAC1 (0.52) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Pentane SCHEMBL28427118 | 0.87 | CHRM1 (0.44) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Isobutane SCHEMBL28426076 | 0.86 | CHRM1 (0.48) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107344976-B | Catalyst component for olefin polymerization, catalyst system and application thereof | 中国石油化工股份有限公司 | 2021-03-16 | — | — | CN | claimed |
| CN-107344979-B | Catalyst component for olefin polymerization, catalyst system and application thereof | 中国石油化工股份有限公司 | 2021-03-16 | — | — | CN | claimed |
| CN-107344980-B | Catalyst component for olefin polymerization, catalyst system and application thereof | 中国石油化工股份有限公司 | 2020-06-09 | — | — | CN | claimed |
| CN-107344976-B | Catalyst component for olefin polymerization, catalyst system and application thereof | 中国石油化工股份有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-107344979-B | Catalyst component for olefin polymerization, catalyst system and application thereof | 中国石油化工股份有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-107344980-B | Catalyst component for olefin polymerization, catalyst system and application thereof | 中国石油化工股份有限公司 | 2020-06-09 | — | — | CN | disclosed |