SCHEMBL28426000

SCHEMBL28426000

CC(C)(C)OC(=O)c1ccc(CN2CCC(c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)c(CN2CCC(c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)c1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ IKZF1 Q13422 5/20 0.65
▸ IKZF2 Q9UKS7 15/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21340262 0.92 IKZF1 (0.68) IKZF1IKZF2
SCHEMBL20765468 0.86 IKZF1 (0.65) IKZF1IKZF2
SCHEMBL20046085 0.82 IKZF2 (0.63) IKZF1IKZF2
SCHEMBL29583366 0.82 IKZF2 (0.63) IKZF1IKZF2
SCHEMBL31333591 0.82 IKZF2 (0.63) IKZF1IKZF2
SCHEMBL31333608 0.81 IKZF1 (0.60) IKZF1IKZF2
SCHEMBL29681184 0.81 IKZF1 (0.60) IKZF1IKZF2
SCHEMBL31333297 0.81 IKZF2 (0.69) IKZF1IKZF2
SCHEMBL20936026 0.81 IKZF1 (0.83) IKZF1IKZF2
SCHEMBL20765355 0.81 IKZF2 (0.74) IKZF1IKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111051298-A 3- (1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof 诺华股份有限公司 2020-04-21 — — CN disclosed
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