Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.60 |
| ▸ | SLC33A1 | O00400 | 2/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891379 | 0.99 | PPARG (0.61) | PPARGSLC33A1AGTR1 | |
| Bromide SCHEMBL1889445 | 0.94 | PPARG (0.59) | PPARGSLC33A1AGTR1 | |
| SCHEMBL1889929 | 0.94 | PPARG (0.63) | PPARGSLC33A1AGTR1 | |
| Bromide SCHEMBL3565943 | 0.94 | PPARG (0.58) | PPARGSLC33A1AGTR1 | |
| SCHEMBL1891644 | 0.93 | PPARG (0.59) | PPARGSLC33A1AGTR1 | |
| Bromide SCHEMBL1890455 | 0.93 | PPARG (0.54) | PPARGSLC33A1AGTR1 | |
| Bromide SCHEMBL1895257 | 0.93 | PPARG (0.68) | PPARGAGTR1 | |
| SCHEMBL1894785 | 0.93 | PPARG (0.59) | PPARGSLC33A1AGTR1 | |
| Hydrochloric Acid SCHEMBL1896020 | 0.93 | PPARG (0.59) | PPARGSLC33A1AGTR1 | |
| SCHEMBL1896115 | 0.93 | PPARG (0.59) | PPARGSLC33A1AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256115-A1 | Heteromonocyclic compound and use thereof | Takeda Pharmaceutical Company Limited (JP) | 2010-12-01 | — | — | EP | disclosed |