Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.78 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.78 |
| ▸ | KDR | P35968 | 9/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.70 |
| ▸ | RET | P07949 | 4/20 | 0.70 |
| ▸ | SRC | P12931 | 3/20 | 0.70 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.70 |
| ▸ | ABL1 | P00519 | 3/20 | 0.70 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.70 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.70 |
| ▸ | PLK4 | O00444 | 2/20 | 0.70 |
| ▸ | AURKA | O14965 | 2/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.70 |
| ▸ | LCK | P06239 | 2/20 | 0.70 |
| ▸ | FYN | P06241 | 2/20 | 0.70 |
| ▸ | LYN | P07948 | 2/20 | 0.70 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.70 |
| ▸ | AXL | P30530 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257980 | 0.94 | RAF1 (0.82) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL1532339 | 0.90 | RAF1 (0.77) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL12391532 | 0.89 | RAF1 (0.76) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL10163311 | 0.89 | RAF1 (0.76) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL19888730 | 0.88 | RAF1 (0.78) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL16620832 | 0.88 | RAF1 (0.74) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL16628087 | 0.87 | KDR (0.83) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL15624828 | 0.87 | RAF1 (1.00) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL4708399 | 0.86 | KDR (0.73) | RAF1EPHX2KDRMAPK14RET | |
| SCHEMBL4732730 | 0.86 | RAF1 (0.71) | RAF1EPHX2KDRMAPK14RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111298127-A | Composition comprising histamine release-promoting substance and inhibitory compound, and oral solid preparation containing the same | 黄泳华 | 2020-06-19 | — | — | CN | claimed |
| CN-111298127-A | Composition comprising histamine release-promoting substance and inhibitory compound, and oral solid preparation containing the same | 黄泳华 | 2020-06-19 | — | — | CN | disclosed |